Full single cell RNA-seq dataset of 428K intestinal cells from fetal, pediatric, adult donors, and up to 11 intestinal regions. Click here to access the paper.
The colon, as a barrier tissue, represents a unique immune environment where immune cells display tolerance toward adiverse community of microbes, which are collectively known as the microbiome.
Colon Schematic Thepublished study revealed that not only were there differences between the immune cells in different parts of the colon, but that the microbiome also subtly changed, with a broader range of bacteria further down the colon.
Image description Single cell transcriptomes for 41,650 cells isolated from the caeacum, transverse colon and sigmoid colon of 5 individuals.
FMedSci FRS
Wellcome Sanger Institute &
University of Cambridge @Teichlab
University Lecturer and
Hon. Consultant
Department of Paediatrics
University of Cambridge
Group Leader
Garvan Institute, Sydney
@KylieReneeJames
PhD candidate
Wellcome Sanger Institute
@elmentaite
MBBS PhD
NIHR Academic Clinical
Fellow and Honorary
Specialty Registrar
in Medical Genetics
University of Cambridge